Watch the video :
Select your hotspot or your popup. Then, in the general properties, click on Animated.
You can see a new key frame in the timeline. This diamond memorizes the position of the hotspot at this specific frame and flag it as a keyframe.
To create another keyframe, go to another timecode. Pause the video and position your interactive element at another place. As soon as you change the position of your element, a second keyframe will appear to register this position.
The interactive element will move smoothly and automatically from the first position to the second position thanks to an automated interpolation between the two positions.